Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Tuberculosis

Shrewd survival strategy

Mycobacterium tuberculosis modulates its virulence to cause persistent but often subclinical infection. This strategy is regulated in part by a feedback loop that controls the secretion of a small subset of bacterial proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genes involved in ESX-1 secretion.

References

  1. Dye, C., Scheele, S., Dolin, P., Pathania, V. & Raviglione, M. C. J. Am. Med. Assoc. 282, 677–686 (1999).

    Article  CAS  Google Scholar 

  2. Raghavan, S., Manzanillo, P., Chan, K., Dovey, C. & Cox, J. S. Nature 454, 717–721 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Sorensen, A. L., Nagai, S., Houen, G., Andersen, P. & Andersen, A. B. Infect. Immun. 63, 1710–1717 (1995).

    Article  CAS  Google Scholar 

  4. Gey van Pittius, N. C. et al. Genome Biol. doi:10.1186/gb-2001-2-10-research0044 (2001).

  5. Converse, S. E. & Cox, J. S. J. Bacteriol. 187, 1238–1245 (2005).

    Article  CAS  Google Scholar 

  6. DiGiuseppe Champion, P. A. & Cox, J. S. Cell Microbiol. 9, 1376–1384 (2007).

    Article  Google Scholar 

  7. Stanley, S. A., Raghavan, S., Hwang, W. W. & Cox, J. S. Proc. Natl Acad. Sci. USA 100, 13001–13006 (2003).

    Article  ADS  CAS  Google Scholar 

  8. van der Wel, N. et al. Cell 129, 1287–1298 (2007).

    Article  CAS  Google Scholar 

  9. Hsu, T. et al. Proc. Natl Acad. Sci. USA 100, 12420–12425 (2003).

    Article  ADS  CAS  Google Scholar 

  10. MacGurn, J. A. & Cox, J. S. Infect. Immun. 75, 2668–2678 (2007).

    Article  CAS  Google Scholar 

  11. MacGurn, J. A., Raghavan, S., Stanley, S. A. & Cox, J. S. Mol. Microbiol. 57, 1653–1663 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Porcelli, S. Shrewd survival strategy. Nature 454, 702–703 (2008). https://doi.org/10.1038/454702a

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/454702a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing