Mycobacterium tuberculosis modulates its virulence to cause persistent but often subclinical infection. This strategy is regulated in part by a feedback loop that controls the secretion of a small subset of bacterial proteins.
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References
Dye, C., Scheele, S., Dolin, P., Pathania, V. & Raviglione, M. C. J. Am. Med. Assoc. 282, 677–686 (1999).
Raghavan, S., Manzanillo, P., Chan, K., Dovey, C. & Cox, J. S. Nature 454, 717–721 (2008).
Sorensen, A. L., Nagai, S., Houen, G., Andersen, P. & Andersen, A. B. Infect. Immun. 63, 1710–1717 (1995).
Gey van Pittius, N. C. et al. Genome Biol. doi:10.1186/gb-2001-2-10-research0044 (2001).
Converse, S. E. & Cox, J. S. J. Bacteriol. 187, 1238–1245 (2005).
DiGiuseppe Champion, P. A. & Cox, J. S. Cell Microbiol. 9, 1376–1384 (2007).
Stanley, S. A., Raghavan, S., Hwang, W. W. & Cox, J. S. Proc. Natl Acad. Sci. USA 100, 13001–13006 (2003).
van der Wel, N. et al. Cell 129, 1287–1298 (2007).
Hsu, T. et al. Proc. Natl Acad. Sci. USA 100, 12420–12425 (2003).
MacGurn, J. A. & Cox, J. S. Infect. Immun. 75, 2668–2678 (2007).
MacGurn, J. A., Raghavan, S., Stanley, S. A. & Cox, J. S. Mol. Microbiol. 57, 1653–1663 (2005).
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Porcelli, S. Shrewd survival strategy. Nature 454, 702–703 (2008). https://doi.org/10.1038/454702a
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DOI: https://doi.org/10.1038/454702a
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