The existing methods of creating genetically modified plants are inefficient and imprecise. Zinc-finger technology offers the prospect of opening up a swifter and more exact route for crop improvement.
This is a preview of subscription content, access via your institution
Access options
References
Shukla, V. K. et al. Nature 459, 437–441 (2009).
Townsend, J. A. et al. Nature 459, 442–445 (2009).
Porteus, M. H. & Carroll, D. Nature Biotechnol. 23, 967–973 (2005).
Lloyd, A., Plaisier, C. L., Carroll, D. & Drews, G. N. Proc. Natl Acad. Sci. USA 102, 2232–2237 (2005).
Cai, C. Q. et al. Plant Mol. Biol. 69, 699–709 (2008).
Maeder, M. L. et al. Mol. Cell 31, 294–301 (2008).
Wright, D. A. et al. Plant J. 44, 693–705 (2005).
Elliot, B., Richardson, C., Winderbaum, J., Nickoloff, J. A. & Jasin, M. Mol. Cell. Biol. 18, 93–101 (1998).
Carroll, D., Morton, J. J., Beumer, K. J. & Segal, D. J. Nature Protoc. 1, 1329–1341 (2006).
Ramirez, C. L. et al. Nature Meth. 5, 374–375 (2008).
Pruett-Miller, S. M., Connelly, J. P., Maeder, M. L., Joung, J. K. & Porteus, M. H. Mol. Ther. 16, 707–717 (2008).
Meng, X., Noyes, M. B., Zhu, L. J., Lawson, N. D. & Wolfe, S. A. Nature Biotechnol. 26, 695–701 (2008).
Durai, S., Bosley, A., Abulencia, A. B., Chandrasegaran, S. & Ostermeier, M. Comb. Chem. High Throughput Screen 9, 301–311 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Porteus, M. Zinc fingers on target. Nature 459, 337–338 (2009). https://doi.org/10.1038/459337a
Published:
Issue date:
DOI: https://doi.org/10.1038/459337a
This article is cited by
-
Low frequency of zinc-finger nuclease-induced mutagenesis in Populus
Molecular Breeding (2016)
