Figure 1: Interpreting the contribution of iron to MRI signal in the substantia nigra of an elderly case without Parkinson's disease. | Nature

Figure 1: Interpreting the contribution of iron to MRI signal in the substantia nigra of an elderly case without Parkinson's disease.

From: Biomarkers: casting the net wide

Figure 1

a, Photograph showing brown deposits of neuromelanin, typically found in dopaminergic neurons (scale bar, 1 mm). b, Corresponding X-ray fluorescence map of iron distribution from low (blue) to high (red) concentration (scale bar, 1 mm). c, T2* MRI microscopy in original block of unfixed tissue (scale bar, 500 μm). For further details, see ref. 6. Picture credits: J. F. Collingwood (a–c), University of Warwick; M. R. Davidson (b), A. Mikhailova (a), J. P. Bullivant (c), V. Antharam (a, c), C. Batich (c) and J. Forder (c), University of Florida; J. Dobson (b), Keele University; and P. D. Quinn (b) and J. F. W. Mosselmans (b), Diamond Light Source.

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