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Basic research: bizarre but essential

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Woodgett, J. Basic research: bizarre but essential. Nature 467, 400 (2010). https://doi.org/10.1038/467400b

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  1. Actually we can stop giving grants to 70 year old professors to study the protonation state of some enzyme that has already been studied to death for the last 50 years.

  2. Speaking of terminological alternatives to "basic research", I recommend the example of my PhD supervisor Brian S. Hartley. He was a founder of Biogen and key member of government committees on biotechnology in the 1980s, so no slouch in the "translation" department. His term for what some would call basic research was "strategic applied research". Much of the discussion in this area rests upon the unspoken assumption that the rate-limiting step in getting useful science is between bench and bedside (or the equivalent in non-biomedical disciplines). While of course there are local bottlenecks at every stage of translation, I would guess that the most rate-limiting step is making discoveries that can be applied. In other words, between the world around us and our understanding of its complexities.

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