Key Points
-
Chemochemical caries removal involves the selective removal of carious dentine. The reagent is prepared by mixing solutions of amino acids and sodium hydrochlorite.
-
Reagents for the procedure were originally marketed as a solution known as Caridex. More recently, a similar system in the form of a gel has been marketed as Carisolv.
-
Being a gel, Carisolv has the advantage of requiring volumes of less than 1 ml. No applicator system other than specially designed instruments is required.
-
Because only carious dentine is removed, the painful removal of sound dentine is avoided and the need for local anaesthesia is minimised.
-
The procedure is suitable for soft carious lesions access to which may still require conventional mechanical procedures.
Abstract
Chemomechanical caries removal involves the chemical softening of carious dentine followed by its removal by gentle excavation. The reagent involved is generated by mixing amino acids with sodium hypochlorite; N-monochloroamino acids are formed which selectively degrade demineralised collagen in carious dentine. The procedure requires 5–15 minutes but avoids the painful removal of sound dentine thereby reducing the need for local anaesthesia. It is well suited to the treatment of deciduous teeth, dental phobics and medically compromised patients. The dentine surface formed is highly irregular and well suited to bonding with composite resin or glass ionomer. When complete caries removal is achieved, the dentine remaining is sound and properly mineralised. The system was originally marketed in the USA in the 1980's as Caridex. Large volumes of solution and a special applicator system were required. A new system, Carisolv, has recently been launched on to the market. This comes as a gel, requires volumes of 0.2–1.0 ml and is accompanied by specially designed instruments.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Ring M E . Dentistry; an Illustrated History. pp 250–251. New York : Abrams, 1985.
Frencken J E, Pilot T, Sangpaison Y, Phantumvanit P . Atraumatic restorative treatment (ART): rationale technique and development. J Public Health Dent 1996; 56: 135–140.
Keller U, Hibst R, Guertsen W, Schilke R, Heidermann D, Klacber B, Raab W H M . Erbium : YAG laser applications in caries therapy: evaluation of patients perception and acceptance. J Dent 1998: 26; 649–656.
Veis A . In Comper W.D. (Ed) Extracellular Matrix, Volume 1 Tissue Function 41–76 Amsterdam: Harwood Academic Press, 1996.
Hall R C, Embery G . The use of immunohistochemistry in understanding the structure and function of the extracellular matrix of dental tissues. Adv Dent Res 1997; 11: 478–486.
Van der Rest M, Bruckner P . Collagens: diversity at the molecular and super molecular levels. Curr Opin Struct Biol 1993; 3: 430–436.
Thylstrup A, Fejerskov O . Text book of Clinical Cariology (2nd ed) 111–157. Copenhagan: Munksgaard 1994.
Ogushi K, Fusayama T . Electron microscopic structures of two layers of carious dentine. J Dent Res 1975; 54: 1019–1026.
Goldman M, Kronman J H . A preliminary report on a chemomechanical means of removing caries. J Amer Dent Assoc 1976; 93: 1149–1153.
Schutzbank S G, Marchwinski M, Kronman J H, Goldman M, Clark R E . A comparative in vitro study of GK-101 and GK-101E in caries removal. J Dent Res 1978; 57: 861–864.
Habib C M, Kronman J, Goldman M . A chemical evaluation of collagen and hydroxyproline after treatment with GK-101 (N-monochloroglycine). Phar Thera Dent 1975; 2;: 209–215.
Yip H K, Beeley J A . Studies on the reaction of NaOCI and NMAB with collagen. J. Dent Res 1989; 68: 982.
Burke F, Lynch E . Chemomechanical caries removal. J Irish Dent Assoc 1995: 41; 10–14.
Yip H K, Beeley J A, Stevenson A G . The interface between carious and sound dentine — an SEM study. Med Sci Res 1991: 19; 187–188.
Burke F M, Lynch E . The effect of chemomechanical caries removal on the bond strength of glass polyalkenoate cement to dentine. J Dent 1994: 22; 283–291.
Kidd E A M, Joyston-Bechel S, Beighton D . Microbiological validation of assessments of caries activity during cavity preparation. Caries Res: 27; 402–408.
Lynch E, Sheerin A, Silwood C J, Grootveld M C . Detection and determination of protein carbonyl adducts in primary root caries. J Dent Res: 76: 1049.
Kleter G A, Damen J J M, Buigus M J, ten Cate J M . Modification of amino acid residues in carious dentine matrix. J Dent Res 1998: 77: 488–495.
Watson T F, Kidd E A M . USA: the Caridex caries removal system. Br Dent J 1986: 161; 461–462.
Yip H K, Stevenson A G, Beeley J A . An improved reagent for chemomechanical removal of dental caries in permanent and deciduous teeth. An in vitro study. J. Dent 1995; 23: 197–204.
Yip H K, Stevenson A G, Beeley J A . Chemomechanical removal of dental caries in deciduous teeth: further studies in vitro. Br Dent J 1999; 186: 179–182.
Bawart O, Moschen I, Graber A, Pfaller K . In vitro study comparing the efficacy of N-monochloro-D, L-2aminobutyrate (NMAB, GK-101E) and water in caries removal. J Oral Rehabil 1991: 18; 535–536.
Yip H K, Beeley J A, Stevenson A G . Mineral content of the dentine remaining after chemomechanical caries removal. Caries Res 1995; 29: 111–117.
Ericson D, Simmerman M, Raber H, Götrick B, Bornstein R . Clinical evaluation of efficacy and safety of a new method for chemomechanical removal of caries. Caries Res 1999; 33: 171–177.
Moran C, Lynch E, Petersson L, Borshboom P . Comparison of caries removal using Carisolv™ or a conventional slow speed rotary instrument. Caries Res 1999; 33: 313.
Banerjee A, Watson T F, Kidd E A M . Carious dentine excavation using Carisolv™ gel: a quantitative autofluorescence assessment using scanning microscopy. Caries Res 1999; 33: 313.
Author information
Authors and Affiliations
Additional information
Refereed Paper
Rights and permissions
About this article
Cite this article
Beeley, J., Yip, H. & Stevenson, A. Chemochemical caries removal: a review of the techniques and latest developments. Br Dent J 188, 427–430 (2000). https://doi.org/10.1038/sj.bdj.4800501
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.bdj.4800501
This article is cited by
-
Short ultrasonic debridement with adjunctive low-concentrated hypochlorite/amino acid gel during periodontal maintenance: randomized clinical trial of 12 months
Clinical Oral Investigations (2020)
-
Effects of air polishing and an amino acid buffered hypochlorite solution to dentin surfaces and periodontal ligament cell survival, attachment, and spreading
Clinical Oral Investigations (2017)
-
Comparative evaluation of effects of chemo-mechanical and conventional caries removal on dentinal morphology and its bonding characteristics — An SEM study
European Archives of Paediatric Dentistry (2012)
-
Fluorescence of primary dentine after chemomechanical and conventional rotary excavation
European Archives of Paediatric Dentistry (2008)
-
Severe Acute Respiratory Syndrome (SARS) and the GDP. Part II: Implications for GDPs
British Dental Journal (2004)


