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Alzheimer's disease: The forgetting gene

For decades, most researchers ignored the leading genetic risk factor for Alzheimer's disease. That is set to change.

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References

  1. Strittmatter, W. J. et al. Proc. Natl Acad. Sci. USA 90, 1977–1981 (1993).

    Article  ADS  CAS  Google Scholar 

  2. Hardy, J. & Allsop, D. Trends Pharmacol. Sci. 12, 383–388 (1991).

    Article  CAS  Google Scholar 

  3. Filippini, N. et al. Proc. Natl Acad. Sci. USA 106, 7209–7214 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Kim, J., Basak, J. M. & Holtzman, D. M. Neuron 63, 287–303 (2009).

    Article  CAS  Google Scholar 

  5. Mahley, R. W. & Huang Y. J. Med. Chem. 55, 8997–9008 (2012).

    Article  CAS  Google Scholar 

  6. Chen, H. K. et al. J. Biol. Chem. 287, 5253–5266 (2012).

    Article  CAS  Google Scholar 

  7. Linnertz, C. et al. Alzheimers Dement. http://dx.doi.org/10.1016/j.jalz.2013.08.280 (2014).

  8. Guerreiro, R. J. & Hardy, J. Arch. Neurol. 69, 1243–1244 (2012).

    Article  Google Scholar 

  9. Sato, T. et al. Neurobiol. Aging 32, 1626–1633 (2011).

    Article  CAS  Google Scholar 

  10. Brookmeyer, R., Gray, S. & Kawas, C. Am. J. Pub. Health 88, 1337–1342 (1998).

    Article  CAS  Google Scholar 

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US National Institute on Aging: Alzheimer's disease genetics

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Spinney, L. Alzheimer's disease: The forgetting gene. Nature 510, 26–28 (2014). https://doi.org/10.1038/510026a

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