Abstract
A combined analysis of genome scans was performed for adult height in the NHLBI Family Blood Pressure Program. Height data were available on 6752 individuals. Linkage analysis was performed first separately for each of the eight ethnic groups in the four networks using the variance component method. To increase the power to detect the common genetic components affecting height for all the individuals, a linkage analysis was performed subsequently for the combined data set by pooling the average allele-sharing IBD () for all groups. By combining the data, we replicated evidence for a QTL influencing adult height on chromosome 7 (7q31) (LOD=2.46), which has been reported in two previous studies. Suggestive linkage (LOD>1) was found in another six regions in our combined analysis. Evidence for linkage for two of these regions (2p12, 20p11) has also been reported previously.
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Acknowledgements
We thank Thomas Dyer from Southwest Foundation for Biomedical Research, San Antonio, TX, USA for his helpful suggestions using SOLAR package. We are grateful to two anonymous reviewers whose constructive comments were very helpful in preparing the paper for publication. We thank Christy Chang of Johns Hopkins University for her discussion of data cleaning. This work was supported by grants from the National Heart, Lung and Blood Institute (UO1 HL54485; HL54466; HL65702; HL54481; HL45508; HL47910; HL51021; HL54464; HL54473; HL54496; HL54472; HL54515; HL54495; HL54471; HL54509; 2HHZ598; HL65702; HL54527).
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Wu, X., Cooper, R., Boerwinkle, E. et al. Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program. Eur J Hum Genet 11, 271–274 (2003). https://doi.org/10.1038/sj.ejhg.5200952
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DOI: https://doi.org/10.1038/sj.ejhg.5200952
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