Abstract
Chronic mucocutaneous candidiases (CMC) are a group of rare disorders where an altered immune response against Candida leads to persistent and/or recurrent infections of the skin, nails, and mucous membranes. We analysed a five-generation Italian family with an isolated form of CMC, affecting nails only, in the presence of low serum concentration of intercellular adhesion molecule I (ICAM-1). We excluded linkage to candidate regions on chromosomes 2p (CMC with thyroid disease), 21q22.3 (APECED), and 19q13 (ICAM-1). We then carried out a genome-wide scan and assigned the CMC locus to a 19 cM pericentromeric region on chromosome 11.
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Mangino, M., Salpietro, D., Zuccarello, D. et al. A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12–q12.1. Eur J Hum Genet 11, 433–436 (2003). https://doi.org/10.1038/sj.ejhg.5200985
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DOI: https://doi.org/10.1038/sj.ejhg.5200985
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