We agree with Becker and Knapp in noting the promise of novel haplotype estimation methods that combine segregation information with the EM approach. Indeed, we concluded our paper in anticipation of such advances:

Methods which incorporate both familial transmission and genotype frequencies, thereby combining the benefits of error detection, segregation patterns and underlying haplotype frequencies, but which are as yet undeveloped, could favour trios and yield more efficient and accurate methods for cataloguing LD patterns.

Methods which incorporate both familial transmission and genotype frequencies, thereby combining the benefits of error detection, segregation patterns and underlying haplotype frequencies, but which are as yet undeveloped, could favour trios and yield more efficient and accurate methods for cataloguing LD patterns.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account
Continue with Google
Continue with ORCiD