Abstract
The first statistical analysis of the French National Registry of volunteer bone marrow donors estimated the probabilities of haplotype frequencies separately for each of the 20 administrative regions of France. Here we propose to use donors' surnames to increase the accuracy of location of the donor's geographical origin. This approach allows us to estimate haplotype frequencies for administrative entities (90 departments) smaller than regions and to correct for bias resulting from recent mobility. We analysed 30 777 donors typed for HLA-A,B and 17 745 donors typed for HLA-A,B,DR,DQ. By using the donors' surnames, we identified common and rare haplotypes (those found in only one department) and estimated the degree of HLA polymorphism at the department level. We also identified departments with a distinctive genetic structure (for example, Paris, Corsica, Pyrenees and Meurthe-et- Moselle). By providing a more accurate geographical distribution of HLA polymorphisms in France, this study will enable us to optimise policies for recruiting bone marrow donors and to improve the fit between the donor file and patients' needs.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Darke C : An overview of the Welsh bone marrow donor registry 10 years of bone marrow donor provision. Bone Marrow Transplant 2000; 25: 771–777.
Dini G, Cancedda R, Locatelli F et al: Unrelated donor marrow transplantation: an update of the experience of the Italian Bone Marrow Transplant Group (GITMO). Haematologica 2000; 85: 30–36.
Ordemann R, Petzold K, Holig K et al: The Dresden Cord Blood Bank. Experiences of the Cord Blood Bank in Dresden, promoted by the German bone Marrow Donor Registry Dtsch Med Wochenschr 2000; 125: 1424–1428.
Velickovic ZM, Carter JM : Feasibility of finding an unrelated bone marrow donor on international registries for New Zealand patients. Bone Marrow Transplant 1999; 23: 291–294.
Gyodi E, Rajczy K, Penzes M et al: Hungarian Bone Marrow Donor Registry: present status and activity. Bone Marrow Transplant. 1998; 22: S38–S40.
Kupkova L, Ivaskova E, Hana I et al: An overview of the Czech Bone Marrow Donor Registry. Bone Marrow Transplant. 1998; 22: S41–S44.
Widmer-Kuhnlein E, Gratwohl A, Kern M et al: 10 years Swiss bone marrow donor registry. Schweiz Med Wochenschr. 1998; 128: 1602–1604.
Martinetti M, Degioanni A, D'Aronzo AM et al: An immunogenetic map of Lombardy (Northern Italy). Ann Hum Genet 2002; 66: 37–48.
Lonjou C, Clayton J, Cambon-Thomsen A, Raffoux C : HLA-A, B, DR haplotypes in France: implications for recruitment of potential bone marrow donors. Transplantation 1995; 60: 375–383.
Crognier E, Bley D, Boetsch G : Mariage en Limousin, Evolution séculaire et idéntité d'une population rurale, le canton de Chateauponsac (1870–1979). Paris: CNRS Editions, 1998.
Darlu P, Degioanni A, Ruffié J : Quelques statistiques sur la distribution des patronymes en France. Population 1997; 3: 607–634.
Schneider S, Kueffer JM, Excoffier L : Arlequin (Version 2000) a Software for Population Genetic Data Analysis. Switzerland: Genetics and Biometry Laboratory University of Geneva, 1997.
Barrai I, Rodriguez-Larralde A, Mamolini E, Manni F, Scapoli C : Elements of the surname structure of Austria. Ann Hum Biol 2000; 27: 607–622.
Mathias RA, Bickel CA, Beaty TH et al: A study of contemporary levels and temporal trends in inbreeding in the Tangier Island, Virginia, population using pedigree data and isonymy. Am J Phy Anthropol 2000; 112: 29–38.
Rodriguez-Larralde A, Morales J, Barrai I : Surname frequency and the isonymy structure of Venezuela. Am J Hum Biol 2000; 12: 352–362.
Lasker GW, Mascie-Taylor CGN : The genetic structure of English villages: surname diversity changes between 1976 and 1997. Ann Hum Biol 2001; 28: 546–553.
Sykes B, Irven C : Surnames and the Y chromosome. Am J Hum Genet 2000; 66: 1417–1419.
Manni F, Barrai I : Genetic structures and linguistic boundaries in Italy: a microregional approach. Hum Biol 2001; 73: 335–347.
Barrai I, Rodriguez-Larralde A, Mamolini E, Manni F, Scapoli C : Isonymy structure of USA population. Am J Phy Anthropol 2001; 114: 109–123.
Barrai I, Rodriguez-Larralde A, Manni F, Scapoli C : Isonymy and isolation by distance in the Netherlands. Hum Biol 2002; 74: 263–283.
Caravello G, Tasso M : Use of surnames for a demo-ecological analysis: a study in southwest Sardinia. Am J Hum Biol 2002; 14: 391–397.
Gagnon A, Toupance B : Testing isonymy with paternal and maternal lineages in the early Quebec population: the impact of polyphyletism and demographic differentials. Am J Phy Anthropol 2002; 117: 334–341.
Chan C : The quality of life of women of Chinese origin. Health Soc Care Community 2000; 8: 212–222.
Garza-Chapa R, De Los Angeles Rojas-Alvarado M, Cerda-Flores RM : Prevalence of NIDDM in Mexicans with paraphyletic and polyphyletic surnames. Am J Hum Biol 2000; 12: 721–728.
De Silvestri A, Guglielmino CR : Ethnicity and malaria affect surname distribution in Consenza Province (Italy). Hum Biol 2000; 72: 573–583.
Pollock BH, DeBaun MR, Camitta BM et al: Racial differences in the survival of childhood B-precursor acute lymphoblastic leukemia a Pediatric Oncology Group Study. J Clin Oncol 2000; 18: 813–823.
Jacobs EA, Lauderdale DS : Receipt of cancer screening procedures among Hispanic and non-Hispanic health maintenance organization members. Cancer 2001; 91: 257–261.
Rudan I : Ancestral kinship and cancer in Lastovo Island, Croatia. Hum Biol 2001; 73: 871–884.
Carta MG, Kovess V, Hardoy MC, Morosini P, Murgia S, Carpiniello B : Psychiatric disorders in Sardinian immigrants to Paris: a comparison with Parisians and Sardinians resident in Sardinia. Soc Psychiatry Psychiatr Epidemiol 2002; 37: 112–117.
Brancatelli G, Federle MP, Grazioli L, Carr BI : Hepatocellular carcinoma in noncirrhotic liver: CT, clinical, and pathologic findings in 39 US residents. Radiology 2002; 222: 89–94.
Darlu P, Ruffie J : Relationships between consanguinity and migration rate from surname distributions and isonymy in France. Ann Hum Biol 1992; 19: 133–137.
Degioanni A, Lisa A, Zei G, Darlu P : Patronymes italiens et migration italienne en France entre 1981 et 1940. Population 1996; 6: 1153–1180.
Darlu P, Degioanni A, Ruffié J : Quelques statistiques sur la distribution des patronymes en France. Population 1997; 3: 607–634.
Legay JM, Vernay M : The distribution and geographical origin of some French surnames. Ann Hum Biol 2000; 27: 587–605.
Vernay M : Trends in inbreeding, isonymy, and repeated pairs of surnames in the Valserine Valley, French Jura, 1763–1972. Hum Biol 2000; 72: 675–692.
Mourrieras B, Darlu P, Hochez J, Hazout S : Surname distribution in France: a distance analysis by a distorted geographical map. Ann Hum Biol 1995; 22: 183–198.
Degioanni A, Darlu P : A Bayesian approach to infer geographical origins of migrants through surnames. Ann Hum Biol 2001; 28: 537–545.
Darlu P, Degioanni A, Jakobi L : Les cloisonnements dans les Pyrénées occidentales. Evolution du XIX siècle à nos jours. In Brunet G, Darlu P, Zei G (eds) Le patronyme. Histoire, anthropologie, société. Paris: CNRS Editions, 2001, pp 173–188.
Degioanni A, Darlu P, Poulain M, Foulon M : Immigration flamande en France au XIX siècle et au débout du XX siècle. In Brunet G, Darlu P, Zei G (eds): Le patronyme. Histoire, anthropologie, société. Paris: CNRS Editions, 2001, pp 189–203.
Boetsch G, Prost M, Rabino-Massa E : Evolution of consanguinity in a French alpine valley: the Vallouise in the Brianfon region (17th–19th Centuries). Hum Biol 2002; 74: 285–300.
Morelli L, Paoli G, Francalacci P : Surname analysis of the Corsican population reveals an agreement with geographical and linguistic structure. J Biosociol Sci 2002; 34: 289–301.
Degioanni A, Lisa A, Zei G, Darlu P : Patronymes italiens et migration italienne en France entre 1981 et 1940. Population 1996; 6: 1153–1180.
Ohayon E, Cambon-Thomsen A : Génétique des Population Humaines, Paris, INSERM 1986.
Cavalli-Sforza LL, Menozzi P, Piazza A : The history and geography of human genes. Englewood Cliffs NJ Princeton University Press, 1994.
Charron D : HLA Genetic Diversity of HLA Functional and Medical Implication. EDK Paris: Dominique Charron, 1997.
Acknowledgements
This work was supported by Grant EFG 1999 and by grant of OHLL CNRS program. We thank all the French typing laboratories and the French donors for their kindness.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Degioanni, A., Darlu, P. & Raffoux, C. Analysis of the French National Registry of unrelated bone marrow donors, using surnames as a tool for improving geographical localisation of HLA haplotypes. Eur J Hum Genet 11, 794–801 (2003). https://doi.org/10.1038/sj.ejhg.5201038
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.ejhg.5201038
Keywords
This article is cited by
-
The internal migration of Indian scientists, 1981–2003, from an analysis of surnames
Scientometrics (2008)
-
Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German population
European Journal of Human Genetics (2006)
