Abstract
In this paper, we review the statistical methods that can be used in isolated populations to map genes involved in complex diseases. Our intention is to highlight the fact that if the features of population isolates may help in the identification of susceptibility factors for complex traits, the choice and design of methods for statistical analysis in these populations deserve particular care. We show that methods designed for outbred samples are generally not appropriate for isolated populations and could lead to false conclusions.
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Acknowledgements
We thank Carole Ober for kindly accepting to let us use the Hutterite pedigree in our simulations and the Genetic Analysis Workshop grant number, GM31575 for GAW12 data. We thank Carole Ober, Françoise Clerget-Darpoux, Marie-Claude Babron and two anonymous reviewers for helpful comments on the manuscript.
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Bourgain, C., Génin, E. Complex trait mapping in isolated populations: Are specific statistical methods required?. Eur J Hum Genet 13, 698–706 (2005). https://doi.org/10.1038/sj.ejhg.5201400
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DOI: https://doi.org/10.1038/sj.ejhg.5201400
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