Abstract
Family trees have long been a valuable visual tool for geneticists in identifying clusters of inherited traits and genotypes. As more data are collected, drawing the graphs by hand becomes impractical and, for this reason, we have developed the pedigree software CraneFoot. It can process any family graph with minimal computational cost by making a pedigree transformation that enables the use of a linear node positioning algorithm. The program is designed for automated drawing to printed media and efficient visual classification of genetically interesting families from large data sets. It also incorporates a robust pedigree topology check with detailed error messages.
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Acknowledgements
This work was conducted with the support of the graduate school of Electrical and Communication Department at Helsinki University of Technology, Jenny and Antti Wihuri Foundation, Folkhälsan Research Center and Academy of Finland Grants for MW (No. 00213) and KK (No. 209286). The Finnish Diabetic Nephropathy Study (FinnDiane) was supported by grants from the Folkhälsan Research Foundation, Samfundet Folkhälsan, the Research Funds of the Helsinki University Central Hospital, the Wilhelm and Else Stockmann Foundation, the Sigrid Juselius Foundation, European Comission (Contract No. QLG2-CT-2001-01669), and the Liv och Hälsa Foundation.
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Mäkinen, VP., Parkkonen, M., Wessman, M. et al. High-throughput pedigree drawing. Eur J Hum Genet 13, 987–989 (2005). https://doi.org/10.1038/sj.ejhg.5201430
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DOI: https://doi.org/10.1038/sj.ejhg.5201430
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