Abstract
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
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Acknowledgements
We thank Professors Pat Jacobs and Newton Morton for their support and advice. This work was funded by the Wellcome Trust.
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Ennis, S., Ward, D. & Murray, A. Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers. Eur J Hum Genet 14, 253–255 (2006). https://doi.org/10.1038/sj.ejhg.5201510
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DOI: https://doi.org/10.1038/sj.ejhg.5201510
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