Abstract
Preeclampsia is a common, pregnancy-specific vascular disorder characterised by hypertension and proteinuria. A recent report suggested association of the STOX1 gene on chromosome 10q22.1 with preeclampsia in the Dutch population. Here, we present a comprehensive assessment of STOX1 as a candidate gene for preeclampsia in the Finnish population by re-examining our previous genetic linkage analysis results for both chromosome 10 and paralogous loci, by genotyping representative markers in a nationwide data set, and by studying STOX1 expression in placentas from preeclamptic and uncomplicated pregnancies. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene.
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Acknowledgements
We thank Hong Jiao, Leena Järvinen, Erja Kerkelä, Riitta Lehtinen, Cecilia M Lindgren and Ville Mäkelä for contributions to the laboratory analyses and all participants of the studies. This study was supported by Swedish Research Council, Academy of Finland, Sigrid Jusélius Foundation, Finnish Medical Foundation, Helsinki University Central Hospital Research Funds, Helsinki University Research Funds, Päivikki and Sakari Sohlberg Foundation and Uusimaa Regional Fund of the Finnish Cultural Foundation.
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Kivinen, K., Peterson, H., Hiltunen, L. et al. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur J Hum Genet 15, 494–497 (2007). https://doi.org/10.1038/sj.ejhg.5201788
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DOI: https://doi.org/10.1038/sj.ejhg.5201788
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