Precision medicine requires a different type of clinical trial that focuses on individual, not average, responses to therapy, says Nicholas J. Schork.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling
Clinical Proteomics Open Access 01 March 2024
-
Bayesian multilevel multivariate logistic regression for superiority decision-making under observable treatment heterogeneity
BMC Medical Research Methodology Open Access 05 October 2023
-
Passive identification of subjective preferences toward individual items using eye-tracking in a virtual reality environment
Virtual Reality Open Access 03 August 2023
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mukherjee, D. & Topol, E. J. Prog. Cardiovasc. Dis. 44, 479–498 (2002).
Currie, G. P., Lee, D. K. & Lipworth, B. J. Drug Saf. 29, 647–656 (2006).
Uryniak, T. et al. Stat. Biopharmaceut. Res. 3, 476–487 (2011).
Druker, B. J. et al. N. Engl. J. Med. 344, 1038–1042 (2001).
Karapetis, C. S. et al. N. Engl. J. Med. 359, 1757–1765 (2008).
Kravitz, R. L. & Duan, N. Design and Implementation of N-of-1 Trials: A User's Guide (Agency for Healthcare Research and Quality, 2014).
Schuffham, P. A. et al. J. Gen. Intern. Med. 25, 906–913 (2010).
Drescher, C. W. et al. J. Clin. Oncol. 31, 387–392 (2013).
Chen, R. et al. Cell 148, 1293–1307 (2012).
US Food and Drug Administration. Paving the Way for Personalized Medicine: FDA's Role in a New Era of Medical Product Development (US Department of Health And Human Services, FDA, 2013).
Author information
Authors and Affiliations
Corresponding author
Supplementary information
Related links
Related links
Related links in Nature Research
California unveils 'precision-medicine' project 2015-Apr-14
Obama to seek $215 million for precision-medicine plan 2015-Jan-30
Medical research: Missing patients 2014-Sep-16
Related external links
Rights and permissions
About this article
Cite this article
Schork, N. Personalized medicine: Time for one-person trials. Nature 520, 609–611 (2015). https://doi.org/10.1038/520609a
Published:
Issue date:
DOI: https://doi.org/10.1038/520609a
This article is cited by
-
Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling
Clinical Proteomics (2024)
-
Bayesian multilevel multivariate logistic regression for superiority decision-making under observable treatment heterogeneity
BMC Medical Research Methodology (2023)
-
Pharmacogenomics: current status and future perspectives
Nature Reviews Genetics (2023)
-
Real World Evidence (RWE) in der Phytotherapie
Zeitschrift für Allgemeinmedizin (2023)
-
Passive identification of subjective preferences toward individual items using eye-tracking in a virtual reality environment
Virtual Reality (2023)
