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Variations in the human CC chemokine eotaxin gene

Genes & Immunity volume 2, pages 461–463 (2001)Cite this article

Abstract

The CC chemokine eotaxin (CCL11) plays a major role in the recruitment and activation of eosinophils in allergic disorders. In the present study, we performed polymorphism screening of the coding and promoter regions of the eotaxin gene (SCYA11). A G to A single nucleotide substitution was detected at position 67, which resulted in a non-conservative amino acid change of Ala at position 23 to Thr (A23T) within the signal peptide. Two single nucleotide substitutions, ie, C to T at position −426 (−426C>T), and A to G at position −384 (−384A>G), were detected in the 5′-flanking regions. Significant linkage disequilibrium was observed between positions −426 and −384, and also between −384 and +67. No significant association was observed between these variations and susceptibility to asthma.

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Acknowledgements

We thank Ms M Imanishi and Ms C Tamura for their invaluable technical assistance. Thanks are also extended to Ms S Takeyama for her excellent secretarial help, and to Dr J Ohashi (Department of Human Genetics, University of Tokyo) for performing the statistical analyses.

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Author notes

  1. M Miyamasu

    Present address: Laboratory of Host Defenses, NIAID, NIH, Bethesda, 20892, MD, USA

Authors and Affiliations

  1. Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    M Miyamasu, T Sekiya & K Yamamoto

  2. Department of Human Genetics, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    N Tsuchiya & K Tokunaga

  3. Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    K Hirai

  4. Department of Internal Medicine, Teikyo University, Japan

    K Ohta

  5. Department of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan

    C Ra

  6. Department of Microbiology, Kinki University School of Medicine, Osaka, Japan

    O Yoshie

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  1. M Miyamasu
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  2. T Sekiya
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Corresponding author

Correspondence to K Hirai.

Additional information

This work was supported by a grant from the Manabe Medical Foundation, and grants-in-aid from the Ministry of Health, Welfare and Labor of Japan, and the Ministry of Education, Science, Sports and Culture of Japan (13204013).

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Miyamasu, M., Sekiya, T., Ohta, K. et al. Variations in the human CC chemokine eotaxin gene . Genes Immun 2, 461–463 (2001). https://doi.org/10.1038/sj.gene.6363807

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  • DOI: https://doi.org/10.1038/sj.gene.6363807

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