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Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren’s syndrome

Genes & Immunity volume 3, pages S63–S65 (2002)Cite this article

Abstract

The immunoglobulin kappa (Km) light chain gene is polymorphic and is believed to play a role in the pathology of infectious and autoimmune diseases. Polymorphisms within the constant region of the Km gene encode three alleles designated Km1, Km1,2 and Km3. Previous studies using serological detection of Km allotypes reported associations between specific Km allotypes, systemic lupus erythematosus and the presence of anti-La antibodies, yet these findings were not confirmed in other studies. In order to more precisely define any associations between Km alleles and anti-Ro/La antibodies we used the polymerase chain reaction and restriction fragment length polymorphisms for Km genotyping in a large cohort of patients with primary Sjögren’s syndrome (SS). No associations were observed between specific Km alleles and primary SS when compared with a control population, nor within serologically defined subsets of SS patients. We conclude that Km alleles are not associated with primary SS or the Ro/La autoantibody response.

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Acknowledgements

Special thanks to Dr G Moxley, Medical College of Virginia, Richmond, USA who kindly donated reference DNA samples. This work was supported by the Australian Red Cross Blood Service and the Arthritis Foundation of Australia Val Provis Grant. We thank members of the Arthritis Foundation of South Australia Lupus/Scleroderma/Sjögren’s support group, and other Sjögren’s syndrome sufferers for their involvement.

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Authors and Affiliations

  1. Department of Rheumatology, The Queen Elizabeth Hospital, Woodville, South Australia

    S Downie-Doyle, S Lester, M Rischmueller & K Pile

  2. Australian Red Cross Blood Services, Adelaide, South Australia

    P Bardy

  3. Department of Immunology, Allergy and Arthritis, Flinders Medical Centre, Bedford Park, South Australia

    T Gordon

Authors
  1. S Downie-Doyle
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  2. S Lester
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  3. P Bardy
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  4. T Gordon
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  5. M Rischmueller
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  6. K Pile
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Corresponding author

Correspondence to M Rischmueller.

Additional information

This study was supported by an Arthritis Foundation of Australia Val Provis Grant.

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Downie-Doyle, S., Lester, S., Bardy, P. et al. Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren’s syndrome. Genes Immun 3 (Suppl 1), S63–S65 (2002). https://doi.org/10.1038/sj.gene.6363853

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