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LymphTF-DB: a database of transcription factors involved in lymphocyte development

Genes & Immunity volume 8, pages 360–365 (2007)Cite this article

Abstract

B and T cells develop following a similar early stepwise progression to later stages where multiple developmental options are available. These developmental regimes necessitate differential gene expression regulated by a large number of transcription factors (TFs). The resultant burgeoning amount of information has opened a knowledge gap between TF activities during lymphocyte development and a researcher's experiments. We have created the LymphTF database (DB) to fill this gap. This DB holds interactions between individual TFs and their specific targets at a given developmental time. By storing such interactions as a function of developmental progression, we hope to advance the elucidation of regulatory networks that guide lymphocyte development. Besides queries for TF-target gene interactions in developmental stages, the DB provides a graphical representation of downloadable target gene regulatory sequences with locations of the transcriptional start sites and TF-binding sites. The LymphTF-DB can be accessed freely on the web at http://www.iupui.edu/~tfinterx/.

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Acknowledgements

We appreciate the comments and suggestions of two anonymous reviewers.

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Authors and Affiliations

  1. School of Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

    P J Childress, R L Fletcher & N B Perumal

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  1. P J Childress
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  2. R L Fletcher
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Correspondence to N B Perumal.

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Childress, P., Fletcher, R. & Perumal, N. LymphTF-DB: a database of transcription factors involved in lymphocyte development. Genes Immun 8, 360–365 (2007). https://doi.org/10.1038/sj.gene.6364386

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