Abstract
Design
Randomised controlled trial (RCT).
Intervention
One hundred and sixty patients participating in a RCT in which they were randomised to multivitamins (n=81) or placebo (n=79) completed ulcer diaries and a weekly telephone survey by calling an automated interactive voice response (IVR) system. Stressful events were quantified using the validated Recent Life Changes Questionnaire (RLCQ) and were classified as mental or physical stressors.
Outcome measure
Onset and duration of RAS episodes
Results
Stressful life events were significantly associated with the onset of RAS episodes (P < 0.001), but not with the duration of the RAS episodes. Experiencing a stressful life event increased the odds of an RAS episode by almost three times (OR = 2.72; 95% CI = 2.04–3.62). When controlled for each other, mental stressors had a larger effect (OR = 3.46, 95% CI = 2.54– 4.72) than physical stressors (OR = 1.44; 95% CI = 1.04– 1.99) on the occurrence of RAS episodes. RAS episodes did not occur more frequently or last longer with increasing stress severity.
Conclusions
In patients with a history of RAS, stressful events may mediate changes involved in the initiation of new RAS episodes. Mental stressors are more strongly associated with RAS episodes than physical stressors.
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Address for correspondence: Dr R Lalla, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA. E-mail: lalla@uchc.edu
Huling LB, Baccaglini L, Choquette L, Feinn RS, Lalla RV. Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med 2012; 41: 149–152. doi: 10.1111/j.1600-0714.2011.01102.x. Epub 2011 Nov 12. PubMed PMID: 22077475
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Keenan, A., Spivakovksy, S. Stress associated with onset of recurrent aphthous stomatitis. Evid Based Dent 14, 25 (2013). https://doi.org/10.1038/sj.ebd.6400919
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DOI: https://doi.org/10.1038/sj.ebd.6400919
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