Abstract
Design
Randomised controlled trial.
Intervention
Patients with a validated history of at least three episodes of idiopathic recurrent aphthous stomatitis were randomised to either a once-daily multivitamin containing 100% of the U.S. reference daily intake (RDI) of essential vitamins or a placebo for at least one year.
Outcome measure
Number of new RAS episodes, mouth pain, normalcy of diet and medication compliance.
Results
There were no significant differences in mean number of new RAS episodes between the multivitamin (4.19 episodes) and placebo (4.60 episodes) groups. Mean duration of new episodes was similar for the two groups at 8.66 days for multivitamin group and 8.99 days for placebo(P = .60). There were no differences with other measures.
Conclusions
Daily multivitamin supplementation, with the RDI of essential vitamins, did not result in a reduction in the number or duration of RAS episodes.
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References
Volkov I, Rudoy I, Freud T, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med 2009; 22: 9–16.
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Authors and Affiliations
Additional information
Address for correspondence: Dr. Lalla, Assistant Professor, Section of Oral Medicine, University of Connecticut Health Center, Farmington, CT 06030-1605, USA. E-mail: lalla@uchc.edu.
Lalla RV, Choquette LE, Feinn RS et al. Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial. J Am Dent Assoc 2012; 143: 370–376. PubMed PMID: 22467697.
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Spivakovsky, S., Keenan, A. No effect seen for multivitamin therapy on recurrent aphthous stomatitis patients. Evid Based Dent 14, 26 (2013). https://doi.org/10.1038/sj.ebd.6400920
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DOI: https://doi.org/10.1038/sj.ebd.6400920
