Figure 1

Effects of herbimycin A (HA) on the cytotoxicity of taxotere in parental HAG-1 and HAG/src3-1cells. Cells were treated with various concentrations of taxotere for 2 h and incubated for an additional 3 days, with or without HA. Cell survival was determined on day 7. Cytotoxicity curves of taxotere for HAG-1 (□) and HAG/src3-1 (○) without HA treatment. HAG-1 cells co-treated with taxotere and 100 ng ml⁻¹ of HA (⋄). HAG/src3-1 cells co-treated with taxotere and 10 (▵), 50 (×) or 100 (▿) ng ml⁻¹ of HA. The data represent the means from five independent experiments. bars, s.d.. The s.d. for all points without error bars is less than 5%.