Figure 1 | British Journal of Cancer

Figure 1

From: Rationale for combination therapy of chronic myelogenous leukaemia with imatinib and irradiation or alkylating agents: implications for pretransplant conditioning

Figure 1

Example for the dose response curve of irradiation in BCR–ABL-positive BV173 cells (A) and the data transformation to allow calculation of the level of growth inhibition at a given dose according to the median effect equation of Chou and Talalay (B). The dose-response relationship is displayed as a linear regression line (r = 0.997). The x-intercept of the median effect-plot (B) represents the median effect dose (Dm, ED50) at which a 50% growth inhibition (Fa = 0.5) occurs. The six data points in A and B correspond to the six original data points of irradiation alone in Table 1 (1st data column). Fa, affected fraction; Fu, unaffected fraction; D, dose.

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