Figure 2 | British Journal of Cancer

Figure 2

From: Rationale for combination therapy of chronic myelogenous leukaemia with imatinib and irradiation or alkylating agents: implications for pretransplant conditioning

Figure 2

Example of a classic isobologram at ED75. Imatinib is combined with γ-irradiation in BV173 cells. The ED75 values were calculated from a series of primary data such as presented in Table 1 using CalcuSyn software. Means of three experiments were calculated and an isobologram was drawn by MS Excel. The three data points shown (a, b, and c) correspond to imatinib [μM]/γ-irradiation [Gy] ratios of 1 : 15, 1 : 7.5 (approximately equitoxic combination), and 1 : 3.75, respectively. The corresponding CI values as calculated following the classic isobologram equation are 0.572, 0.583, and 0.593. As CI values of <1 express synergism, imatinib + γ-rradiation represents an example of a strongly synergistic combination.

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