Figure 2

Representative tracings of MABP and the hydrogen gas clearance curve. Upward arrow, start of 9% H₂ inhalation; N, clearance curve in kidney cortex (normal tissue); T, clearance curve in tumour growing in the kidney; downward arrow, starting point of i.v. injection of 10 mg kg⁻¹ ml⁻¹ AC7700; the bold line at the bottom, chart speed 3 cm min⁻¹; the thin line at the bottom, chart speed 60 mm min⁻¹. Tissue blood flow was calculated from the half-life of H₂ washout. Before AC7700 administration, tissue blood flow in the normal kidney cortex and tumour was 157.5 and 30.9 ml min⁻¹ 100 g⁻¹, respectively. After AC7700 was administered i.v., MABP transiently decreased from 113 to 80 mmHg and then immediately increased to 157 mmHg. Under AC7700-induced hypertension, although tissue blood flow in the kidney cortex showed almost no change (150.7 ml min⁻¹ 100 g⁻¹), the TBF decreased to 13.8 ml min⁻¹ 100 g⁻¹.