Figure 4
Antitumour effect of AC7700 against tumours growing in various tissues. The left side in each panel shows results for the group given 0.9% NaCl (eight rats); the right side in each panel shows results for the group treated with 10 mg kg−1 AC7700 (eight rats). The sum of tumours that appeared in rats in each group is shown in each panel. (A) tumours in the lung; (B) tumours in the liver; (C) tumours in the myocardium; (D) tumours in the subcutis; (E) lymph node metastases (mediastinale, coeliacum, mesentericum, lumbare); (F) changes in body weight of tumour-bearing rats during AC7700 treatment. (A–C), mean tumour area±s.d. (mm2) in the maximum sections of the left lung, the left lobe of the liver, and the myocardium of the left ventricle. (D) and (E) mean tumour weight±s.d. (g) in the subcutis and lymph node metastases. Tumour size in the lung and subcutis in the AC7700-treated group was significantly smaller than that in the 0.9% NaCl-treated group (lung tumour, P=0.0228; subcutaneous tumour, P<0.0001). The number of lymph node metastases was significantly smaller in the AC7700-treated group compared with the control group (P=0.0054). There was no significant difference in body weight between the two groups.
