Figure 6
Contraction of a host arteriole and a tumour-feeding arteriole caused by 10 mg kg−1 AC7700. (A) before AC7700 administration; (B) 5 min later; (C) 30 min later; (D) 3 h later. Tumour blood flow completely stopped 30 min after i.v. administration of AC7700. Note that an arteriole (white arrow) underwent marked contraction in response to AC7700, and a feeding arteriole (asterisk) into a tumour disappeared from view. Original magnification, × 20. Bar, 250 μm.
