Figure 2
From: Anti-tumour activity and toxicity of the new prodrug9-aminocamptothecin glucuronide (9ACG) in mice
Influence of age and sex on 9ACG toxicity. Male (A–C) and female (D–F) mice aged 5 weeks (A, D), 10 weeks (B, E) or 20 weeks (C, F) were i.v. injected with 50 mg kg−1 9ACG or s.c. injected with 5 mg kg−1 9AC. Body mass was followed and compared to non-treated animals of the same age and sex. Mean weights of three mice relative to initial body weights are shown. Significant differences between drug and control groups at weight nadirs are indicated: *P⩽0.05; **P⩽0.005. Bars, s.e.
