Figure 5
In vitro experiments. (A) VEGF production by 4T1 cells. SC-236 or Indomethacin at 5 or 10 μM significantly reduced VEGF production (pg VEGF μg−1 total protein) relative to controls (*P<0.001 in all cases). There was no significant difference between SC-236 or indomethacin treatment at either dose. Data represent mean±s.e.m. of three experiments carried out in triplicate. (B) 4T1 apoptosis. SC-236 or Indomethacin at 5 or 10 μM significantly increased the percentage of apoptotic cells relative to controls (*P<0.001 in all cases). There was no significant difference between SC-236 or indomethacin treatment at either dose. Data represent mean±s.e.m. of three experiments carried out in triplicate.
