Figure 1
Growth arrest and differentiation in LNCaP cells. Treatment with 10−7 M R1881 suppressed the growth of LNCaP cells as documented by (A) reduced incorporation of tritiated thymidine. Western blotting (B,C) demonstrated (B) upregulation of the cell cycle inhibitor p27/Kip-1 and the differentiation marker E-cadherin (C) after R1881 treatment. (D) Protein staining with Coomassie blue served as loading control.
