Figure 1
From: Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1
Mean (±s.e.m.) fold induction (relative to normoxia; top panel), firefly LUC (middle panel) and Renilla LUC (bottom panel) detected in MCF-7 cells following transfection with the pGL3 Promoter vector, or this containing trimerised versions of the SARE, the human EPO HRE, the human ALD HRE or the murine PGK-1 HRE. Cells were exposed to 0, 0.5, 1 or 21% O2 for 16 h. *P<0.05 with respect to the same trimer at 0.5% O2 (unpaired t-test). Pooled data from three experiments are shown.
