Figure 6

Inhibition of 3LL-cell-induced angiogenesis by KIN-841 as determined using the mouse dorsal air sac method. Dorsal skin of the mice 7 days after implantation of a chamber filled with PBS alone (A) or 3LL cells (B and C). The implanted mice were treated with 200 mg kg⁻¹ day⁻¹ of KIN-841 for 4 days between days 1 and 6, intraperitoneally (C). In (D), the grade of angiogenesis induced by 3LL cells is shown using the indexes described in Materials and Methods. ^aP<0.01 tumour-free controls; ^bP<0.05 vs tumour controls.