Figure 2
Immunohistochemical staining of VEGFR-3 and VEGF-D in endothelial cells adjacent to carcinoma. (A) VEGFR-3-positive lymphatic and vascular endothelial cells (scale bar, 25 mm). (B) VEGFR-3 staining highlighted vessel invasion by carcinoma cells (arrows) (scale bar, 25 mm). VEGF-D-positive endothelial cells (C) in vessels invaded by ovarian carcinoma was positive for VEGFR-3 (D) (scale bars 25 mm). Arrows on each inset show endothelia that were positive for VEGF-D (C) or VEGFR-3 (D). Asterisks on each inset reveal carcinoma cell (scale bars on inset, 12.5 mm).
