Figure 2 | British Journal of Cancer

Figure 2

From: Noninvasive estimation of tumour viability in a xenograft model of human neuroblastoma with proton magnetic resonance spectroscopy (1H MRS)

Figure 2

(A–C) TE dependence of spectra obtained from a largely necrotic xenograft. (A): TE=20 ms. MLs dominate over a large range of chemical shifts (0–3 ppm) and obscure the Lac doublet resonance at 1.33 ppm. (B) TE=135 ms. MLs have been reduced by faster T2 relaxation to the level of Cho. Interference of Lac (inverse at 135 ms) with residual lipid resonances is clearly seen. (C) TE=200 ms. Relaxation differentiation on long T2 metabolites (Cho, Lac). The fast relaxing ML signal has vanished exhibiting the lactate doublet (antiphase dispersion lines).

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