Figure 4

(A) Overview of small, homogeneous tumour (HE). (B) Same tumour as in A (TUNEL and HE). Apoptotic cells brown (arrows). Cell undergoing mitosis is marked with arrowhead. (C) Large untreated tumour with extensive central necrosis (CN) and a peripheral viable tumour tissue (VT) (HE); (D) Same tumour as in C (TUNEL). (E) Overview of a tumour treated with TNP-470 (HE). Note multiple small round perivascular cuffs of tumour cells surrounded by extensive necrosis and haemorrhage. (F) Same tumour as in E (TUNEL). Scale bar=2 mm applies to A and C. Scale bar in B=25 μm, in D=500 μm, in E=1 mm, in F=250 μm, respectively.