Figure 2
From: Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids
Invasion into foetal brain aggregates. Confrontation of U87MG spheroids (T) with a 21-day-old foetal rat brain aggregate (B). (A–C) Volume growth of the tumour spheroids is noticeably reduced at 20 μg ml−1 temozolomide concentration compared to untreated controls (D–F). As a consequence of this, reduced invasion capacity is observed.
