Figure 5
From: Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids
Senescence-associated galactosidase activity in glioma spheroids treated with temozolomide. X-Gal staining revealed that GaMG spheroids never accumulate a detectable galactosidase activity as a response to temozolomide treatment. However, U87 cells clearly exhibit a drug-dependent stimulation of galactosidase activity. This accumulation of lysosomal galactosidase enzyme is already observed shortly after drug application.
