Table 1 Expression of hAG-3 and hAG-2 mRNA in 46 breast cancer samples

From: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan

Gene

Biological marker

mRNA copy number median (range)

Statistical significance

hAG-2

ER+

13000 (2900–160 000)

P=0.01

 

ER−

4500 (130–78 000)

 

hAG-3

ER+

5774 (88–30 573)

P=0.004

 

ER−

183 (5–16 961)

 

hAG-2

Age⩾50 years

11 000 (130–160 000)

P=0.75

 

Age<50 years

8900 (600–130 000)

 

hAG-3

Age⩾50 years

3738 (12–30 573)

P=0.05

 

Age<50 years

903 (5–6608)

 

hAG-2

EGFR−

16 000 (130–160 000)

P=0.009

 

EGFR+

5650 (290–17 000)

 

hAG-3

EGFR−

5774 (63–30 573)

P=0.003

 

EGFR+

233 (5–13 216)

 

hAG-2

Tumour Grade I, II

12 500 (150–160 000)

P=0.09

 

Tumour Grade III

4950 (130–130 000)

 

hAG-3

Tumour Grade I, II

6295 (282–30 573)

P=0.006

 

Tumour Grade III

183 (5–16 961)

 
  1. hAG-2 and hAG-3 expression in 46 clinical breast cancer samples was quantified by real time RT-PCR. mRNA copy number per ng cDNA was correlated with ER status (+, positive: −negative), age (less than 50 years of age versus 50 years of age and over), EGFR status, and tumour grade (grades I and II vs grade III). Statistical significance was calculated using the Mann Whitney U-test.
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