Figure 1
From: Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma
Vascular phenotype in reactive and neoplastic lymph nodes. LH39-positive meshwork in (A) a reactive lymph node (B) a follicular lymphoma and (C) a large B-cell lymphoma; in the latter only a few residual fragments of the LH39 meshwork are present (arrow). (D) Reactive lymph nodes: all the vessels in the paracortex are within the LH39 meshwork while (E) LH39-negative vessels are present within a germinal centre. (F) Only rare LH39-negative vessels are seen in the paracortex in Follicular lymphomas (arrow) while (G) some more are present in the neoplastic follicles (arrows). Sequence of vascular regression: (H) A normal vessel in which the endothelial cells and the LH39-positive basal membrane are superimposed. (I) early detachment of the endothelial cells from the basal membrane. (J,K) Progressive fragmentation of both endothelial cells and basal membrane leading to vascular regression.
