Table 5 Summary of angiogenesis-related features in lymph nodes (data from the present paper, Stewart et al (2002) and Doussis-Anagnostopoulou et al (1997))
From: Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma
(A) Reactive germinal centres, neoplastic follicles and diffuse large cell NHL | |||
|---|---|---|---|
NHL | Reactive germinal centres | Neoplastic follicles | Diffuse large B cell |
MVD | 69.7 | 63 | 185 |
Mature LH39%+ | 79.6% | 76.5% | 50% |
LH39 meshwork | Lysis | Lysis | Lysis |
αVβ3+ | 6.3% | 43% | 62.7% |
Regressing vessels | 9% | 10.6% | 0.4% |
Hif1a | +21/25 (84%) | +17/30(56%) | 37/48(77%) |
Hif2a | Mac | Mac | Mac++ |
CA IX nuclear | Mac (several) | Mac (several) | Mac (few) |
CA IX membrane | Absent | Absent | 7 out of 48 (15%) |
VEGF | Mac | Neoplastic cells | Neoplastic cells |
TP cells | Mac/FDR | Mac/FDR | Dendritic like cells |
(B) Paracortex from reactive lymph nodes, paracortex in lymph nodes with follicular lymphoma and diffuse large cell NHL | |||
NHL | Reactive LN paracortex | FL lymph node paracortex | Diffuse large B cell |
MVD | 287 | 180 | 185 |
Mature LH39%+ | 100% | 90.95% | 50% |
LH39 meshwork | Present | Present | Lysis |
αVβ3+ | 20.7% | 66% | 62.7% |
Regressing vessels | 0.2% | 0.2% | 0.4% |
Hif1a | Rare | Rare | 37 out of 48 cases (77%) |
Hif2a | Several | Several | mac++ |
CA IX nuclear | Absent | Absent | Mac (few) |
CA IX membrane | Absent | Absent | 7 out of 48 cases (15%) |
VEGF | Mac few | Neoplastic cells | Neoplastic cells |
TP | Mac/IDR | Mac/IDR | Dendritic-like |
