Table 3 Associations between prostate cancer and three markers in the TH-INS-IGF2 genomic region – among non-diabetic Black and Caucasian subjects (n=68 pairs)

From: Polymorphism of the insulin gene is associated with increased prostate cancer risk

 

Adjusted OR (95% CI) a

P

+1127 INS-PstI

  

 CT or TT

1

 

 CC

3.57 (1.35–9.45)

0.010

−4217 TH-PstI

  

 TT

1

 

 CT

2.27 (0.99–5.19)

0.053

 CC

1.72 (0.55–5.42)

0.355

+3580 IGF2-MspIb

  

 GG

1

 

 AG

0.90 (0.42–1.95)

0.797

 AA

1.52 (0.37–6.27)

0.559

  1. aOdds ratios were adjusted for the other two markers in the model.
  2. bIGF2 is subject to parental imprinting, and only the paternal allele is expressed. OR for the heterozygous genotype was difficult to interpret, when the expressing allele (A or G) was not identified. Conversely, knowing the active allele among the subjects with homozygous AA or GG was irrelevant. Hence, the OR for the homozygous AA was fully interpretable when the homozygous GG was used as the reference.
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