Table 2 Number of patients with WHO grade 3 or 4 toxicities and response by dose level (no. of patients=23)

From: Phase I/II study of gemcitabine plus mitoxantrone as salvage chemotherapy in metastatic breast cancer

 

Dose level

 

1

2

3

4

5

Patients treated

3

5

5

5

5

Gemcitabine (mg m−2)

600

800

1000

1200

600

Mitoxantrone (mg m−2)

10

10

10

10

12

Toxicity

     

 Neutropenia (DLT)

—

2

2

3

3

 Thrombocytopenia

—

—

1

—

2

 Anaemia

—

—

—

—

1

 Vomiting

—

—

—

1

—

  1. WHO=World Health Organization; DLT=dose-limiting toxicities.
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