Table 4 Cardiac toxicities in patients who received mitoxantrone

From: Phase I/II study of gemcitabine plus mitoxantrone as salvage chemotherapy in metastatic breast cancer

 

Cumulative

LVEF %

  

Patients no. 5

dose (mg m−2)

Before

After

Prior anthracyclines (mg m−2)

Symptom and sign

(1) Phase I

45

55

40

Doxo 300

Asymptomatic

(2) Phase I

65

55

45

Doxo 280

Asymptomatic

(3) Phase II

20

55

43

Epi 480

Asymptomatic

(4) Phase II

40

50

37

Epi 480

Tachycardia

(5) Phase II

50

60

45

Epi 450

Asymptomatic

  1. Epi=epidoxorubicin, Doxo=doxorubicin.
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