Figure 5
(A) Caspase-3 activity in HepG2 cells after wortmannin (10 μ M) and/or Taxol (0.1 μ M) treatment for 24 h. *P<0.001 as compared with wortmannin alone treatment; #P<0.01 as compared with Taxol alone treatment, (B) Effect of a dominant-negative AKT1 expression vector (dn AKT) and control vector (vector) in combination with 0.1 μ M Taxol on caspase-3 activation. Caspase-3 activation is shown as fold of respective transient transfection control groups.
