Table 2 Transcapillary transfera of capecitabine and its metabolites to malignant and healthy tissues
Ratio of AUC 0−5 h | Capecitabine | DFCR | DFUR | FU |
|---|---|---|---|---|
Tumour/plasma | 1.76 | 0.67 | 0.53 | 0.66 |
(0.54–7.07) | (0.45–2.97) | (0.28–2.56) | (0–5.56) | |
s.c. Tissue/plasma | 1.31 | 0.67 | 0.44 | 1.53 |
(0.46–16.7) | (0.41–2.60) | (0.25–1.36) | (0.32–3.38) | |
Tumour/s.c. tissue | 1.11 | 1.12 | 1.20 | 0.66 |
(0.36–1.99) | (0.55–1.93) | (0.60–3.07) | (0–17.5) | |
aRatios are reported as median and range in parentheses as calculated from each single patient (n=10). See Table 1. | ||||
