Figure 1

(A) Arithmetic means of concentrations of urinary HP and LP: in groups 1 (OSCC with mandibular bone infiltration, n=17), 2 (OSCC without mandibular bone infiltration, n=12), 3 (recurrence of OSCC, n=13) and 4 (control group, n=74). Dotted lines mark HP_max (95 nmol mmol⁻¹ creatinine) and LP_max (20 nmol mmol⁻¹ creatinine). The urinary levels of HP in groups 1–3 are significantly different from group 4. The urinary concentrations of LP in groups 1 and 3 are significantly different from group 4. Moreover, in groups 1 and 3, the average urinary content of HP and LP exceeded HP_max and LP_max significantly. Please note that in group 2, HP is significantly elevated as a marker of increased tissue turnover as compared to group 4, but does not exceed HP_max. Length of vertical bars: standard deviation times 1.96. (B) Medians of concentrations of urinary HP and LP: Each box shows the median, quartiles and extreme values of groups 1 (OSCC with mandibular bone infiltration, n=17), 2 (OSCC without mandibular bone infiltration, n=12), 3 (recurrence of OSCC, n=13) and 4 (control group, n=74). Lines mark HP_max (95 nmol mmol⁻¹ creatinine) and LP_max (20 nmol mmol⁻¹ creatinine). The urinary levels of HP in groups 1–3 are significantly different from group 4. The urinary concentrations of LP in groups 1 and 3 are significantly different from group 4. Moreover, in groups 1 and 3, the urinary content of HP and LP exceeded HP_max and LP_max, significantly. As regards groups 1 and 2, the LP_max line is separating LP values, completely. O and * label values of one patient, which significantly exceeded the normal range in the recurrence group.