Table 3 p53 mutations detected in this study; details of the histology of the patients bearing p53 mutations are included, along with details of the mutation itself (base change, amino-acid change)

From: Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology

Patient number

Histological stage

Mutations per biopsy

Mutated p53 condon

p53 mutation

Amino-acid change

2

HGD

1/2

1 at 248

cgg-cag

Arg-Gln

3

HGD

2/4

2 at 248

cgg-cag

Arg-Gln

4

HGD

7/8

7 at 248

cgg-cag

Arg-Gln

6

BM

2/5

2 at 248

cgg-cag

Arg-Gln

8

HGD

2/5

2 at 248

cgg-cag

Arg-Gln

12

BM

1/2

1 at 175

cgc-cac

Arg-His

13

LGD

2/6

1 at 175

cgc-tgc

Arg-Gln

   

1 at 248

cgg-cag

Arg-Cys

18

BM

1/1

1 at 248

cgg-cag

Arg-Gln

26

LGD

2/2

2 at 282

cgg-cgt

No change

31

LGD

1/2

1 at 248

cgg-cag

Arg-Gln

33

BM

1/2

1 at 248

cgg-tgg

Arg-Trp

38

LGD

3/2

2 at 248

cgg-cag

Arg-Gln

   

1 at 175

cgc-cac

Arg-His

42

HGD

1/1

1 at 248

cgg-tgg

Arg-Trp

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