Figure 6 | British Journal of Cancer

Figure 6

From: Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1–5

Figure 6

Adenovirus-mediated expression of K1–5 in Ad/K1–5-transduced TCC-SUP cells and tumour xenografts, and its effect on intratumoral vascularisation. Expressions of K1–5 in TCC-SUP cells (A) infected with Ad/K1–5 at an MOI of 2 or (B) mock-infected were determined by immunostained with rabbit antibody against human K1–3 (× 200 magnification). Expressions of K1–5 in TCC-SUP bladder tumour xenografts after treatment with (C) Ad/K1–5 or (D) PBS (× 200 magnification). Reduction of intratumoral vascularisation (E, G) in Ad/K1–5-treated tumours, but not in (F, H) PBS-treated tumours determined by immunostained with factor VIII (× 100 magnification). The arrows indicate the location of microvessels. The insets in G and H represent the magnified area (× 400 magnification).

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