Figure 6

Cytotoxicity studies. (A) Sensitivity of HU-V-EC (○) and SK-OV-3 cells (•) to treatment with the prodrug CMDA. Arrowheads show the maximum concentrations of CMDA that the HU-V-EC (▿) and SK-OV-3 cells (▾) cells can tolerate without measurable cell death. (B) Effect on the survival of HU-V-EC cells of preincubation with CPG2(Q)3-H₆, CPG2(Q)3-VEGF109-H₆, or VEGF115CPG2(Q)3-H₆, at doses of 0.5 nm (plain bars), 5 nm (shaded bars), or 50 nm (filled bars) and subsequent treatment with 500 μ M CMDA. (C) Sensitivity of HU-V-EC and SK-OV-3 cells to CMDA challenge (500 and 1000 μ M, respectively) after a 30 min incubation with 50 nm VEGF₁₁₅CPG2(Q)3-H₆.