Table 1 Zoledronic acid (ZOL) induces apoptosis in MDA-MB-231 cells only at high concentrations

From: New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects

  

ZOL ( μ M)

 
 

Control

0.01

0.1

1

10

100

Taxol

Annexin V

7.9±1.7

12.6±2.3

8.2±2.8

9.9±3.2

13.7±2.6

35.2*±5.3

64.2**±4.8

Propidium iodide

4.2±1.8

6.7±2.3

5.9±3.1

5.6±2.9

6.5±1.2

5.1±1.9

6.9±2.5

  1. Confluent MDA-MB-231 cells were incubated for 18 h with ZOL at indicated concentrations. Taxol was used as positive control. Results are the mean±s.e.m. of three independent experiments and are expressed as the percentage of positive cells (Bold indicates significance; *P<0.05, **P<0.01).
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