Table 3 Effect of zoledronic acid (ZOL) on the expression of chemokine receptor CXCR-4 on MDA-MB-231 cells

From: New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects

  

ZOL (1  μ M)

 

Control

ZOL (1  μ M)

+GGOH

+FOH

C3 Exo.

59.8±3.1

15.7**±2.3

18.6±4.7

13.1±1.5

47.5±6.1

  1. MDA-MB-231 cells were treated or not by 1 μ M ZOL with or without geranylgeraniol (GGOH) and farnesol (FOH). The effect of ZOL was compared with that of C3 exoenzyme (C3 Exo). The chemokine receptor of SDF-1, CXCR-4, was detected by flow cytometry by indirect immunofluorescence using an FITC-conjugated anti-mouse Ab. Results are the mean±s.e.m. of four independent experiments and are expressed as the percentage of positive cells (Bold indicates significance; **P<0.01).
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